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Cook macaroni and cheese according to package directions using milk and butter.
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Meanwhile, make taco meat by heating oil in skillet and browning the ground turkey; add taco seasoning and water and cook until liquid evaporates; set aside.
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Make Taco Panko Crumbs by mixing oil, panko crumbs and taco seasoning in a small skillet over medium heat; stir until light brown; remove from heat.
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When macaroni and cheese is done, stir in taco meat. Divide into serving bowls and top with avocado, salsa, chopped onions, taco panko crumbs and any other favorite toppings you wish.